沙美特罗/丙酸氟替卡松干粉剂与丙酸氟替卡松气雾剂治疗中度支气管哮喘的疗效比较

Evaluation of the efficacy of the salmeterol/fluticasone propionate turbuhaler compared with fluticasone metered daerosal in the treatment of moderate asthma

目的:比较吸入沙美特罗/丙酸氟替卡松(SM/FP)干粉剂和单用丙酸氟替卡松(FP)气雾剂治疗中度哮喘患者的临床疗效。方法:将60例哮喘患者随机分为两组,A组吸入SM/FP,每次50!g/100!g,Bid,B组吸入FP,每次125!g,Bid。两组均治疗1个月。两组患者治疗前、治疗后即时、治疗后1个月测定晨间最大呼气流量(PEFam),第一秒用力呼气容积占预计值百分比(FEV1%pre),第一秒用力呼气容积占用力肺活量百分比(FEV1/FVC),症状评分。结果:两组各项指标均有好转,治疗后即时PEFam,FEV1%预计值,症状评分A组较B组改善明显,治疗后1个月两组之间各项指标均有差异,A组优于B组(P<0.05)。A组沙丁胺醇气雾剂用药揿数较B组明显减少(P<0.01)。A组完全控制数较B组高。结论:联合吸入低剂量糖皮质激素和2β受体激动剂较单一吸入激素效果好。

Objective：To investigate the effect of salmeterol/fluticasone combination therapy compared to fluticasone in the treatment of asthma.nethods：Sirty patients with moderate asthma were rdomly divided into two groups,30 patients in group A were given SM/FP （50μg/100μg） twice daily,while 30 patients in group B were given FP 125μg twice daily.PEFam,FEV1%pre,FEV1/FVC and the day-and nignt-time asthma symptom scores were measured before and after treatment with salmeterol/fluticasone or fluticasone respectively.Results： There were significant changes in all the indexes in both two groups,PEFam,FEV1%pre, symptom scores were different between the two groups after one month （P〈0.05）,there were significant difference between the two groups after four months（P〈0.05）.The use of salmeterol decreased all the iterms significantly in Group A than in Group B.Concluslons：Combined use corticosteroids and 132 recsptor agonist is superior to the simple inhaled corticosteroids.