糖尿病患者甘油三酯/高密度脂蛋白胆固醇比值水平与胰岛素抵抗的关系

The Relation between Triglyceride/High Density Lipoprotein Cholesterol Ratio and Insulin Resistance in Diabetics

目的探讨血清甘油三酯/高密度脂蛋白胆固醇(TG/HDL-C)比值水平与胰岛素抵抗的关系。方法对146例2型糖尿病患者测定空腹胰岛素(FINS)、空腹血糖(FBG),TG,HDL-C,低密度脂蛋白胆固醇(LDL-C)水平,计算TG/HDL-C比值,并按TG/HDL-C和FBG水平分组,比较组间差异与胰岛素抵抗指数(HOMA-IR)的关系。结果糖尿病组TG/HDL-C比值水平(2.531±3.741)显著高于正常对照组(0.898±0.487),差异有显著性(t=4.279,P<0.001)。TG/HDL-C比值增高组HOMA-IR(3.291±2.004)明显高于TG/HDL-C比值正常组(2.403±1.789),差异有显著性(t=2.796,P<0.01)。血糖水平>10 mmol/L组HOMA-IR(3.575±2.216)明显大于血糖水平≤10mmol/L组(2.384±1.584),差异有显著性(t=3.760,P<0.001)。结论糖尿病患者TG/HDL-C比值水平与胰岛素抵抗存在着密切的相关性。

Objective To study the relation between triglyceride/high density lipopretein-cholesterol （TG/HDL-C） ratio level in serum and insulin resistance （IR） in diabetes. Methods Parameters, such as fast insulin （FINS） , fast blood glucose （FBG）, TG, HDL-C, low density lipoprotein-eholesterol （LDL-C） , were measured in 146 patients with diabetes Ⅱ. TG/ HDL-C ratio was calculated. The patients were divided into several groups according to serum TG/HDL-C ratio and FBG level. Results TG/HDL-C ratio of diabetic group （2.531 ± 3. 741 ） was obviously higher than that of normal control group （ 0. 898 ± 0. 487） , and the difference between them was notably significant （ t = 4. 279, P 〈 0. 001 ）. Homostasis model assessment （HOMA） -IR （ 3. 291 ± 2.004） of the group whose TG/HDL-C ratio was increased was obviously higher than that （2.403 ± 1. 799 ） ot the group with normal TG/HDL-C ratio, and the difference between them was notably significant （ t = 2. 796, P 〈 0.01 ）. HOMA-IR （3. 575 ± 2. 216） of the group with higher FBG level （ 〉 10 mmol/L） was higher obviously than that （ 2. 384 ± 1. 584） of the group with lower FBG level （ ≤ 10 mmol/L） , and the difference between them was notably significant （ t = 3. 760, P 〈 0. 001 ）. Conclusion There is a compact correlation between TG/HDL-C ratio and insulin resistance in diabetes.