癫痫患者脑脊液肿瘤坏死因子的变化

Changes in Tumor Necrosis Factor in Cerebral Spinal Fluid of Patients with Epilepsy

目的 检测癫痫患者血清及脑脊液（CSF）中的肿瘤坏死因子-a（TNF-α）含量，以探讨其所介导的神经免疫机制在癫痫中的作用。方法 分别测定46例癫痛患者和32例对照者血清和CSF中TNF-a含量，并进行比较。结果 癫痫组CSF和血清中TNF-α均明显高于对照组（P〈0．05），其中CSF中TNF-a含量明显高于血清（P〈0．05）；不同病程癫痫患者CSF和血清TNF-a含量有显著差异。病程5-10年组和病程≥10年组较病程≤5年组CSF和血清TNF-a含量均明显增高（P〈0．05）。结论 癫痫患者体内存在由TNF-α介导的神经免疫功能紊乱，并随病程延长而呈加重趋势。

Objective To detect tumor necrosis factor-or （TNF-α） in cerebral spinal fluid （CSF） and serum of the patients with epilepsy so that its neural and immune mechanism could be discussed in the pathogenesis of the disease. Methods Detection ot TNF-α level in CSF and serum was performed respectively in 46 patients with epilepsy and 32 healthy controls, and then comparison was done between the two groups. Results The TNF-α levels both in CSF and serum were higher in the patient group than in the control group （ P 〈 0. 05 ）, and CSF possessed higher TNF-α level than serum （ P 〈 0. 05 ）. Furthermore, the patients＇TNF-α level in CSF and serum varied obviously with the course of the disease. The patients with shorter than or equal to five years＂ course had lower TNF-α level in CSF and serum than those with longer course （P 〈 0. 05）. Conclusion Neural and immune disorder transmitted by change jn TNF-α existed in the patients with epilepsy, and it is inclined to worsen with the disease＇s development.