甲钴胺联合得宝松局部封闭治疗带状疱疹神经痛的疗效观察

Therapeutic Effect of Local Nerve Blockage with Mecobalamin Plus Diprospan on Neuralgia Resulting from Herpes Zoster

目的观察甲钴胺联合得宝松局部注射治疗带状疱疹神经痛的疗效。方法将64例带状疱疹患者,随机分为2组:治疗组给予甲钴胺500μg、得宝松1 m l沿受累神经分布区域皮下点状封闭,1次/d,连续3周。对照组不用得宝松,其他方法、治疗时间与治疗组相同。观察受累神经疼痛症状改善情况及后遗神经痛发生情况。结果治疗组有效率为84.4%,疼痛基本消失时间平均(8.62±1.97)d;对照组有效率为68.7%,疼痛基本消失时间平均(12.14±2.16)d。两组比较差异显著(P<0.01及P<0.05)。结论甲钴胺联合得宝松局部封闭可明显缓解带状疱疹神经痛,能缩短疼痛时间及减少后遗神经痛的发生。

Objective To observe the therapeutic effect of mecobalamin plus diprospan on neuralgia resulting from herpes zoster. Methods All the 64 patients with herpes zoster were divided into two groups at random. The treatment group were additionally administered with mecobalamin （500 μg） and diprospan （1 mg） daily via hypodermic injection along involved nerve band for three weeks, which were not applied to eontrol group. Results The effective rate was 84.4% and the mean pain - disappearing time was 8.62±1.97 days in the treatment group, while the two counterparts were 68.7% and 12.14 ±2. 16 days in the control group. There were significant differences in the parameters between the two groups （ P 〈 0.01, P 〈 0.05 ）. Conclusion Meeobalamin plus diprospan, which can shorten pain duration, is clearly effective on the improvement of neuralgia resulting from herpes zoster.