胎次效应与儿童情感性障碍的风险性研究

Study on relationship between birth order effect and risk of child affective disorder

目的探讨儿童情感性障碍与胎次效应的关系。方法对47例儿童情感障碍患者的病史资料,包括胎次、母孕期状况、出生年月、出生时父母年龄及精神病家族史等进行整理分析,同时将有关资料代入Ha1dane和Smith(HS)公式,且以未受累同胞作对照,并进行比较分析。结果无论样本总体,还是男性或女性,儿童情感性障碍与胎次的关系均非常密切(C值均>2,P值均<0.01,6A均>M)。结论胎次越高,发生儿童情感性障碍的可能性越大。注重优生优育对防止儿童情感性障碍的发生具有重要意义。

Objective To explore the relationship between birth order effect and the risk of child affective disorder. Methods Such history data of 47 children with affective disorder as birth order, maternal conditions of pregnancy, birth date, parent ages at birthday and family history of psychoses were studied by Haldane and Smith procedures and compared with uninvolved sibs. Results Birth orders were significantly related to the risk of child affective disorder （P〈0.01）. Conclusion The higher the birth order, the more vulnerable to child affective disorder. The finding suggests that raising healthier and better-educated children plays an important role in preventing child affective disorder.