肝癌腹水瘤细胞系H_（ca）－F_（25）／CL－16A_3及A_2对宿主红细胞

The changes of red blood cell and lynphoid organs LPO and SOD levels of the hosts bearlng highly and lowmetastatic tumor line

本文利用腹水型肝癌不同转移力瘤株（Ｈｃａ－Ｆ２５／ｃＬ－１６Ａ３及Ａ２）攻击６１５小鼠，观察瘤细胞对宿主红细胞及淋巴样器官过氧化与抗氧化作用的影响。结果发现，荷瘤宿主红细胞及淋巴样器官ＳＯＤ／ＬＰＯ比值变化特征为：荷瘤组显著低于正常组，１６Ａ３组显著低于Ａ２组，但两瘤株使以上指标变化程度不同，这可能与瘤株的免疫原性不同有关。这些结果提示，肿瘤的发生发展与宿主淋巴样器官中过氧化反应的加强与抗氧化酶活性的下降有密切关系，值得进一步探讨。

In this paper,we use Hca-F25/CL-16A3 and A2 to attack 615 mice and observed the influence of tumor lines on the superoxidation and antioxidation of RBC and lymphoid organs.The results showed hat SOD/LPO ratio of tumor-bearing groups is obviously lower than that of the control group.The ratio of the group bearing highly metastatic line is much lower than that of the low-metastatic group.However,the ratio change extent is different.This may be related to different immunogenicity of tumor lines.These results suggested that the occuring and development of tumors are closely related to the increase of peroxidation and the decrease of antioxidative activities.It is worth to do further investigation.