阿昔洛韦联合抗乙肝核糖核酸治疗慢性乙肝的疗效分析

Therapeutic effect of acyclovir and anti-HBV-IRNA treatment on chronic Hepatitis B

乙型肝炎病毒在人体内持续复制是引起肝功能损伤和免疫功能紊乱的主要因素。因此清除乙肝病毒、中止病毒复制是治疗慢性乙肝的重要环节。本文对６０例慢乙肝患者联合应用阿昔洛韦、抗乙肝核糖核酸治疗，结果发现，治疗组与对照组ＨＢＶ复制阴转率比较差异显著，治疗组三项血清ＨＢＶ复制标志全部阴转者５例，而对照组无一例阴转。提示这两组药物联合应用对乙肝病毒具有明显的抑制作用。

Persistent replication of HBV is main factor in bring abnormality of liver function and disturbance of immunoregulation.So clearing HBV and inhibiting viral replication are key link in treatment.60 patients with chronic hepatitis B have been treated by acyclovir and anti-HBV-IRNA.The negative seroconversion ratl of HBV replication markers shows significant diference compared with controls.5 negative seroconversion cases in study group and none in control group.The result indicates combined therapy of acyclovir and anti-HBV-IRNA is more effective in inhibiting HBV replication.