复方仙灵脾透皮软膏的制备及药理作用研究

Preparation of Compound Xianling-branded Transdermal Ointment and Its Pharmacological Action Study

目的:制备复方仙灵脾透皮软膏,并探讨其药理作用。方法:将处方中各中药材采用蒸馏水煮醇沉法提取,所得挥发油溶于阿佐酮中,再加O/W型乳膏基质及药材提取物浸膏混匀,即得。另将本品对小白鼠行壮阳(抗疲劳、耐寒性、体重增加)、♂小白鼠交配能力、♂幼龄小白鼠性器官增重比较实验。结果:本品外观浅棕色,质地爽滑细腻,稀稠适中,手感良好,易于涂敷和清洗,且稳定性好。本品对雄性小白鼠有壮阳作用,并可增强♂小白鼠的交配能力及增加♂幼龄小白鼠性器官重量。结论:本品对阳痿有确切疗效。

OBJECTIVE： To prepare Compound xianling-branded transdermal ointment and to discuss its pharmacological action. METHODS： The Chinese crude drugs in the formula were extracted by distilled water boiling and alcohol precipitation method, then the extracted essential oils were dissolved in azone,and then mixed with O/W cream-base and drug extracts to prepare the end product. Furthermore, the comparative experiment was made in mus musulus albus to test the effects of the ointment on strengthening of masculinity（anti- fatigue cold endurance, and weight gain） in mus musulus albus, mating ability in male mus musulus albus, and weight gain of sex organs in young male mus musulus albus. RESULTS： The prepared product was light brown in appearance, smooth and delicate in quality, suitable in density, felt good and was easy to spread and clean. Besides, the preparation was stable in action. The preparation could strengthen masculinity and mating ability in male mus musulus albus, and increase the weight of sex organs in young male mus musulus albus.CONCLUSION： The preparation has confirmed therapeutic effect on impotence.