钙镁合剂联合谷胱甘肽和卡马西平预防奥沙利铂神经毒性疗效观察

Observation on Preventive Effect of Ca/Mg Infusion Combined with Glutathione and Carbamazepine on Oxaliplatin-induced Neurotoxicity

目的:观察钙镁合剂联合谷胱甘肽和卡马西平预防奥沙利铂神经毒性的疗效。方法:65例接受奥沙利铂、5-氟尿嘧啶、亚叶酸钙治疗的胃肠道肿瘤患者,治疗组接受钙镁合剂联合谷胱甘肽和卡马西平治疗,对照组未接受相应预防治疗。结果:3周期后,治疗组出现临床神经毒性的有7例,而对照组有17例,有统计学差异(P=0.036);12周期后,治疗组中出现2～3度神经毒性有2例,而对照组有9例,有统计学差异(P=0.022)。结论:钙镁合剂联合谷胱甘肽和卡马西平能预防奥沙利铂神经毒性。

OBJECTIVE：To observe the preventive effect of Ca/Mg infusion combined with glutathione and carbamazepine on oxaliplatin- induced neurotoxicity.METHODS：65 patients treated with oxaliplatin, 5-fluorouracil and leucovorin for gastrointestinal cancer were divided into treatment group undergoing treatment with Ca/ Mg infusion combined with glutathione and earbamazepine, and control group without any preventive treatment.RESULTS：At the third cycle, 7 patients in the treatment group but 17 patients in the control group showed clinically evident neurotoxicity, which demonstrated the statistical difference between the two groups（P =0.036）.After 12 cycles, neurotoxicity of grade 2 to 3 was observed in 2 patients in the treatment group but in 9 patients in the control group, which demonstrated the statistical difference between the two groups （P = 0.022） .CONCLUSION ：Ca/Mg infusions combined with glutathione and carbamazepine can prevent oxaliplatin- induced neurotoxicity.