归芪合剂联合氯沙坦治疗糖尿病肾病临床疗效观察

Clinical Observation on Therapeutic Effects of Combined Use of Astragalus and Angelica Composition & Losartan in Treating Diabetic Nephropathy

目的:观察归芪合剂联合氯沙坦治疗糖尿病肾病(DN)的疗效。方法:80例DN患者随机分为治疗组与对照组,治疗组在对照组传统的降糖、激素治疗基础上,加用氯沙坦、归芪合剂,连用8wk,观察治疗前、后空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(GHbA1c)、24h尿蛋白、尿素氮(BUN)、血肌酐(Cr)指标变化。结果:治疗组治疗后24h尿蛋白、BUN、Cr,与对照组治疗后比较有明显下降(P<0.01);治疗组与对照组总有效率分别为90.0%、62.5%(P<0.01)。结论:归芪合剂联合氯沙坦治疗DN疗效好。

OBJECTIVE： To observe the therapeutic effects of astragalus and angelica（A＆A） composition in combination with losartan in treating diabetic nephropathy DN.METHODS： 80 patients with DN were randomly allocated into treatment and control group.A＆A composition in combination with losartan were administered continuously for 8wk in treatment group in addition to the conventional treatment with anti- hyperglycemies and hormone in control group .The indices of FPG, 2hPG, GHbA1c, 24hUAER, BUN, and Cr were observed before and after treatment, and the results were compared. RESULTS： 90.0%, 62.5% （P 〈 0.01） , 24h UAER, BUN and Cr in treatment group decreased significantly（P 〈 0.01）, as compared with control group. The total effective rates in treatment and control group were 90.0 % and 62.5% （P 〈 0.01）, respectively. CONCLUSION ：A＆A composition in combination with losartan is effective in treating DN.