西诺沙星的合成工艺研究

Synthesis of Cinoxacin

本论文合成了西诺沙星及几个关键中间体:N-(3,4-亚甲二氧基苯基)亚肼基氰乙酸乙酯、N-(3,4-亚甲二氧基苯基)-N-乙基亚肼基氰乙酸乙酯、N-(3,4-亚甲二氧基苯基)-N-乙基亚肼基氰基乙酸、1-乙基-3-氰基-6,7-亚甲二氧基-4-噌啉酮.

OBJECTIVE The article introduced one method to synthesis the intermediates of einoxacin：N-（3,4-methyl-enedioxy phenyl） hydrazinelenecyaniethylaeetate; N-（3,4-methylenedioxyphenyl）-N-ethylhydrazinelenecyaniethylacetate; N-（ 3, 4-methylenedioxyphenyl） hydrazineleneeyaniethanoic ; 1-ethyl-3-cyanide-6,7-met hylenedioxy-4-einnolinedone.