摘要
目的选择最佳的缓冲溶液以提高聚维酮碘凝胶的稳定性。方法采用30℃和40℃加速试验考察无缓冲溶液和不同缓冲溶液(磷酸盐缓冲溶液,枸橼酸盐缓冲溶液)对聚维酮碘凝胶稳定性的影响。结果经加速试验6个月后,枸橼酸盐缓冲溶液(0.2 mol/L)的聚维酮碘凝胶Ⅴ的各项考察指标都合格;而其他组的聚维酮碘凝胶的有效碘含量、pH值则大幅度下降,且均有不合格。结论枸橼酸盐缓冲溶液是制备聚维酮碘凝胶最佳的缓冲液,有利于提高聚维酮碘凝胶的稳定性。
Objective Screen for the best buffer solution to improve the stability of the povidone-iodine gel.Method The influences of non-buffer and different buffers(phosphate buffer solution and Citrate buffer solution)on the stability of povidone-iodine gel were investigated by accelerated tests at 30 ℃and 40 ℃.Result After 6 months of accelerated tests,each of the parameters of povidone-iodine gel Ⅴ with Citrate buffer solution(0.2 mol/L) is eligible,the others are not eligible with the sharp decrease in pH values and the content of available iodine.Conclusion Citrate buffer solution is the best solution for the preparation of povidone-iodine gel and the solution is helpful to improve the stability of the gel.
出处
《现代食品与药品杂志》
2006年第2期37-39,共3页
JOurnal of Modern Food and Pharmaceuticals
关键词
聚维酮碘凝胶
缓冲溶液
加速试验
povidone-iodine gel
buffer solution
accelerated test