摘要
目的探讨血管生成素2(Ang-2)与肿瘤的血管发生、入侵/转移能力和肝癌(HCC)预后之间的关系。方法采用免疫组织化学的方法检测Ang-2在肝癌、癌旁和正常肝组织中的表达。结果106例患者中,肝癌组织Ang2表达阳性的例数为63例(59.4%),Ang-2表达阳性的患者和表达阴性患者相比,很多方面有统计学差异(P<0.01),包括更低的组织学分期、门静脉侵犯(69.1%)等。Ang-2阳性表达的患者预后较差。结论肝癌Ang-2的表达和HCC的血管新生、入侵、恶性程度及疾病预后有关。
Objective To study the expression of Ang-2 in hepatocellular carcinoma （HCC）, and its relationship with angiogenesis, invasion and prognosis of HCC. Methods The expression of Ang-2 in HCC was determined by means of immunohistochemistry. Results The expression of Ang-2 in HCC was significantly correlated with pathological stage and invasion of portal vein （P〈0.05）. It had poor prognosis when Ang-2 expressed positive and there was tumor thrombus in portal vein （ P 〈 0.05 ）. Conclusions Expression of Ang-2 could induce angiogenesis of HCC, and had obvious relation with the invasion, malignancy and prognosis of HCC.
出处
《实用临床医药杂志》
CAS
2006年第2期44-46,共3页
Journal of Clinical Medicine in Practice
基金
江苏省医学135重点人才基金
关键词
肝细胞性肝癌(HCC)
血管生成素2
预后
hepatocellular carcinoma
angiopoietin-2
tumor thrombus in portal vein
prognosis
