血管性痴呆患者体质调查

Investigation into Constitutions of Patients with Vascular Dementia

目的:探讨血管性痴呆(vascu lar dem entia,VaD)患者体质特点,研究VaD发病体质因素。方法:采用病例-病例对照的方法,66例VaD患者和51例无认知损害的脑梗塞患者(简称卒中组)对照。B ristol最新神经心理量表中文修订版评价认知功能,B lessed行为量表(BBS)评价生活能力。VaD诊断基于DSMⅣ-、NINDS-AIREN、CDR的标准;Hach insk i缺血量表和Cornell抑郁量表(CSDD)用于鉴别诊断。定式表格调查体质,王琦分型法进行体质诊断。结果:VaD组与卒中组体质主型都以阴虚质最多(分别为31.8%和45.1%),其次是痰湿质(分别为30.3%和35.3%)。VaD组阳虚质和气虚质(分别15.2%和12.1%)高于卒中组(2.0%和5.9%),两组阳虚质比较具有显著性差异(P<0.05)。结论:相对于一般无认知损害的脑梗塞患者,VaD发病的体质因素,除了阴虚质、痰湿质以外,阳虚质是较重要因素,故改善阳虚体质对预防VaD有一定积极作用。

Objective： To explore the constitution characteristics in patients with vascular dementia （VaD）, and to analysis the constitutional risk factor in VaD. Methods： This was a case-case control study. 66 VaD patients and 51 stroke patients were selected by MMSE and Similarities test in WAIS-R, Blessed Behavior Scale. The diagnosis of VaD based on the DSM-Ⅳ and the NINDS-AIREN criteria, Hachinski Ischemia Scale, Cornell Scale of Depression in Dementia and the Clinical Dementia Rating. The stroke group was of MMSE≥28. The structured questionnaire of constitution was used to investigate and Wang Qi＇s method was used to constitution diagnose. Results ： Yin Deficiency was the most common type in the VaD group and the stroke group （31.8% vs 45.1% ）, and the second was Phlegm-Damp （30. 3% vs 35.3% ） ,The frequencies of Yang Deficiency （ 15.2% vs 2%, P 〈 0. 05 ） and Qi Deficiency （12. 1% vs 5.9% ） were higher in VaD group. Conclusion： Yang Deficiency maybe the risk factor for VaD. The constitutions were correlated with pathogenesis in VaD. There was a certain positive effect of improving Yang Deficiency constitution in preventing VaD,