摘要
目的探讨猫抓病(COS)淋巴结组织学形态、免疫组化特点及临床表现。方法对19例COS患者手术活检标本进行组织学及免疫组化观察并结合临床进行分析。结果19例COS患者均有与猫密切接触史,并伴局部淋巴结肿大。组织学特点:肉芽肿性小脓肿形成伴有组织细胞、淋巴细胞、免疫母细胞增生。免疫组化表达:CEA(-)、EMA(-)、CD45(+)、CD20(+)、CD45RO(+)、CD68(++)。结论COS是一种汉赛巴尔通体经猫抓、咬人体后而引起自限性感染性疾病,淋巴结组织学特征、免疫组化表达、临床病史对COS的诊断及鉴别诊断具有重要意义。
Objective To explore the histopathological features, immunohistochemical characteristics and clinical manifestation of lymph nodes in patients with cat- scratch disease （CSD）. Methods Nineteen cases of lymph nodes of CSD were analyzed by histopathological and immunohistochemical techniques. Results All patients with CSD had a clear history of close contact with cats. The local lymph nodes were punctured swelling. The histopathological characteristics were granulomatous small abscess, lymphocytes and immunoblastic cells growing. CEA （ - ）, EMA （ - ）, CD45（ ＋ ）, CD20（ ＋ ）, CD45sRO （ ＋ ） and CD68 （ ＋ ＋ ） were observed in immunohistochemistry. Conclusion CSD is a self- limited infectious disease caused by cat scratching and biting, its pathogen is bartoneUa henselae. Its histopathological characteristics, immunohistochemical expressions and clinical history have very important meaning for the diagnosis and differential diagnosis of CSD.
出处
《中国医师进修杂志》
2006年第4期13-14,共2页
Chinese Journal of Postgraduates of Medicine
关键词
猫抓病
淋巴结炎
免疫组织化学
Cat- scratch disease
Lymphadenitis
Immunohistochemistry
