多巴胺D_3受体基因多态性与精神分裂症

Association between Ser9Gly polymorphism in dopamine D_3 receptor gene and schizophrenia

目的:探讨沈阳地区汉族人群中多巴胺D3受体基因(DRD3)第一外显子第9密码子A→G单核苷酸置换多态性(Ser9Gly多态)与精神分裂症的关联。方法:采用聚合酶链反应-限制性内切酶片断长度多态性(PCR-RFLP)技术对70例精神分裂症患者、94名健康对照者进行基因分型鉴定。比较患者组与对照组DRD3多态性分布频率、精神分裂症早发组与非早发组基因分布频率差异,并与其他国家人群进行比较。结果:患者组与对照组之间等位基因分布无明显差异,早发组与非早发组亦未发现明显差异,而该位点等位基因分布频率与巴西、英国人群有明显差异。结论:研究人群中未发现DRD3基因Ser9Gly多态与精神分裂症存在明显关联。

Objective： To explore the association of dopamine D3 receptor （DRD3） gene Ser9Gly polymorphism with schizophrenia subtypes in Chinese Hart population from Shenyang. Method：The case-control association study was used to analyze the association of polymorphism in the DRD3 gene exon I with 70 schizophrenics and 94 normal controls. Results： No significant differences in genotypes and alleles frequencies of Ser9Gly polymorphism in DRD3 were observed between schizophrenic patients and controls. When patients were divided according to age of onset, the differences were still not significant. But there were significant differences of Ser9Gly genotype distribution between samples in different geographical areas, Condusion：There is no significant association between DRD3 gene Ser9Gly polymorphism and schizophrenia.