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阿立哌唑与利培酮治疗精神分裂症对照研究 被引量:7

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摘要 目的:探讨阿立哌唑与利培酮治疗首发精神分裂症的疗效及不良反应。方法:将符合中国精神障碍分类与诊断标准第3版诊断标准的62例首发精神分裂症患者,随机平分为阿立哌唑组与利培酮组。疗程6周。采用阳性与阴性症状量表(PANSS)及副反应量表(TESS)评定疗效和不良反应。结果:阿立哌唑组显效率及有效率分别为64.5%和90.3%,利培酮组分别为61.3%和87.0%,两组疗效相仿(P>0.05)。阿立哌唑组在治疗2周末阴性症状因子分即有明显下降,而利培酮组在治疗4周末才显著下降。阿立哌唑在锥体外系反应,体质量(体重)增加,月经改变等少于利培酮。结论:阿立哌唑对首发精神分裂症的疗效与利培酮相仿,不良反应轻微,阴性症状改善较快。
出处 《临床精神医学杂志》 2006年第2期110-111,共2页 Journal of Clinical Psychiatry
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