奎硫平短期治疗阿尔茨海默病与血管性痴呆精神行为症状的疗效比较

Effects Comparison of Short-term Quetiapine Therapy on Behavioral and Psychological Symptoms Between Alzheimer's Disease and Vascular Dementia

目的 观察奎硫平短期治疗阿尔茨海默病（AD）与血管性痴呆（VD）精神行为症状的疗效。方法 入选AD患者23例，VD患者27例，均给予奎硫平口服，25-400mg·d^-1，疗程8周，采用痴呆病理行为评定量表（BEHAVEAD）评价精神行为症状及疗效，治疗时出现的症状（TESS）量表评价不良反应。结果 两组患者各评价因子治疗开始后2，4，8周均平稳上升。治疗后两组患者各因子有效率均差异无显著性。结论 奎硫平短期治疗AD和VD均有效，且疗效相近。

Objective To compare the effects of quetiapine on behavioral and psychological symptoms （BPS） between Alzheimer＇s disease （AD） and vascular dementia （VD）. Methods Twenty-three cases of AD with BPS and 27 cases of VD with BPS were recruited, quetiapine （25 -400 mg · d·^1 ） was prescribed for 8 weeks. BPS were evaluated with the Behavioral Pathology in Alzheimer＇s disease Rating Scale （ BEHAVE-AD）, adverse events were evaluated with TESS. Results The efficiency rates in delusions, hallucinations, activity disturbances, aggressiveness, diurnal rhythm disturbances, affective disturbances, and anxieties and phobias were increased gradually in the 2nd week, 4th week, and 8th week after treatment. The difference in efficiency rates of quetiapine on sub-factors between 2 groups was not statistically significant. Conclusion Short term quetiapine therapy is efficient in the treatment of BPS in both AD and VD with similar therapeutic effects.