精神分裂症患儿利司培酮治疗前后血清瘦素和白细胞介素-1β变化的意义

Changes and Significances of Serum Leptin and Interleukin-1β before and after Treatment with Risperidone in Children with Schizophrenics

目的探讨精神分裂症患儿利司培酮治疗前后血清瘦素和白细胞介素-1β(IL-1β)水平的变化及意义。方法观察组31例精神分裂症患儿,利司培酮治疗前和治疗8周后分别测量身高、体质量以计算体质量指数(BMI),用放射免疫法检测其空腹血清瘦素和IL-1β。选取31例健康儿童作为对照组。结果观察组治疗后BMI、血清瘦素水平均明显上升,与治疗前相比差异均有显著性(P均<0.05);观察组血清IL-1β水平在治疗前与对照组相比明显增高,治疗后明显下降,与治疗前相比差异有显著性(P<0.05)。结论首发精神分裂症患儿血清IL-1β水平明显升高,利司培酮治疗后易出现药源性肥胖,低IL-1β水平可能是瘦素抵抗的原因之一。

Objective To explore the changes and significances of serum leptin and interleukin - 1β（ IL- 1β）before and after treatment with risperidone in children with schizophrenics. Methods Thirty - one cases with first - episode children with schizophrenia were chosen in patient group. Their body weight and height were measured before and 8 weeks after treatment with risperidone to calculate the body mass index（BMI）, and their fasting srum lcptin and IL - 1β were assayed radio immunity method. Thirty - one healthy controls were measured at the same time. Results BMI and the level of serum leptin in patients of post - treatment increased significantly compared with those of pre- treatment （all P 〈 0.05 ）. The level of serum IL - 1β in patients of pre treatment was significantly higher compared with that of controls, the level of serum IL - 1β after treatment decreased significantly（ P 〈 0.05 ）. Conclusions The serum IL - 1β level is higher in first - episode children with schizophrenia. Obesity is easy to be seen in the patients treated with risperidone. It may be one of reasons to leptin resistence to decrease serum IL-1β levels.