身材矮小儿童523例病因分析

Etiologic Analysis of 523 Children with Short Stature

目的探讨身材矮小儿童的病因。方法矮小儿童共523例,其中男365例(69.79%),女158例(30.21%);平均年龄10.91岁。对其进行全面的病史采集和体格检查及相关实验室检查。结果生长激素缺乏症115例占21.99%;体质性青春发育延迟100例占19.12%;家族性矮小97例占18.55%;特发性矮小79例占15.11%,余为甲状腺功能减低症、宫内发育迟缓、Turner综合征、多种垂体激素缺乏症等引起的矮小症。结论矮小儿童中,内分泌疾病所致矮小占大多数,其中以生长激素缺乏症最为多见。对部分临床表现不典型的甲状腺功能减低症需通过实验室检查才能确诊。对矮小患儿应明确病因,给予对因治疗。

Objective To explore the etiologic investigation of 523 children with short stature. Methods Five hundred and twentythree children were collected, among them 365 were males （69.79%）, 158 were females （30.21% ）, the average age was （10.91 ± 3.64） years, All of the children were collected detail medical history and taken Doth physical and laboratory examination. Results One hundred and fifteen cases （21.99 % ） were diagnosed as growth hormone deficiency（GHD）, 100 cases （19.12 % ） were diagnosed as constitutional delay of growth and puberty, 97 cases （ 18.55 % ） were diagnosed as familial short stature, 79 eases（ 15.11% ） were diagnosed as idiopathic short stature. The rest of the short statures were attribute for the other reaons. Conclusions Endocrinopathy can cause short stature. GHD is a common diseasse among them. Some hypothyroidism has not special countenance and has no difference in intelligence development from others,so the investigation of thyroid function is important for thence children. For short stature children, correct treatment is according to the pathogeny. After an assessment of short stature has been made, appropriate therapy may be instituted.