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rhPLD2可降低豚鼠慢性哮喘模型血液中PAF的含量 被引量:2

Reductive effect of rhPLD2 on PAF content in serum of guinea pig model with chronic asthma
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摘要 目的:研究人重组磷脂酶D2(rhPLD2)变构体的生物学功能。方法:采用由鸡卵白蛋白(Ovalbumin,OVA)诱导的豚鼠慢性哮喘模型,通过血小板聚集法以观察rhPLD2对哮喘中PAF的作用。结果:rhPLD2可显著降低豚鼠慢性哮喘模型血清中的PAF含量;与NS组相比较P<0.01。结论:rhPLD2在体内具有一定的抗哮喘炎症的生物学功能。 Objective:To study the biologic function of rhPLD2 mutation form. Methods:To adapt the guinea pig chronic asthma model was induced by OVA, the functions of rhPLD2 on PAF was observed through the assay of platelet congregating. Results:rhPLD2 remarkably reduced the lever of PAF in the serum of guinea pig chronic asthma model; compares with the NS group, the P 〈 0. 01. Conclusion:rhPLD2 has the certain biological function of antiasthmatic inflammation in vivo.
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2006年第4期360-363,共4页 Chinese Journal of Immunology
基金 福建省科技攻关重点项目(2004Y010) 福建省产业技术研究开发项目(200504)
关键词 人磷脂酶D2 哮喘 模型 血小板活化因子 Human phospholipase D2 Asthma Model PAF
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  • 1Fujimoto K,Kubo K,Matsuzawa Y et al.Eosinophil cationic protein levels in induced sputum correlate with the severity of bronchial asthma[J].Chest,1997;112(5):1241-1247.
  • 2William R A.Review of the preclinical and clinical data of newer intranasal steroids used in the treatment of allergic rhinitis[J].J Allergy Clin Immunol,1999;104:150-158.
  • 3Li X M,Huang C K,Zhang T F et al.The Chinese herbal medicine formula MSSM-02 suppresses allergic airway hyperreactivity and modulates TH1/TH2 responses in a murine model of allergi asthma[J].J Allergy Clin Immunol,2000;106:660-668.
  • 4Akio M,Osamu K,Koji O et al.Control of IL-5 production by human helper T cells as a treatment fotr eosinophilic inflammation:comparison of in vitro and in vivo effects between selective and nonselective cytokine synthesis inhibitors[J].J Allergy Clin Immunol,2000;106:58-64.
  • 5Qian C G,Huang S B,Garahan L L.Anti-inflammatory activities of LDP-392,A dual PAF receptor antagonist and 5-lipoxygenase inhibitor[J].Pharmacological Research,2001;44(3):213-220.
  • 6Sea-Yuong J,Euk-Ah K,Yong-Woon M et al.Nithic oxide mediates platelet activating factor-induced microvascular leakage in rat airways[J].Ann Otol Laryngol,2001;110:83-86.
  • 7Zen-ichiro H,Satoshi I,Takao S et al.Platelet-activating factor receptor[J].2002;131(6):773-779.
  • 8Karim N,Franz V,Andreas M et al.Inactivation of a testis-specific lis1 transcript in mice prevents spermatid differentiation and causes male infertility[J].Biochem J,2002;131(5):635-640.
  • 9Benveniste J,Henson P M,Conchrane.Leukocyte-dependent histamine release from rabbit platelets.The role of IgE,basophils and platelet-activating factor[J].J Exp Med,1972;136:1356-1377.
  • 10Chao W,Olson M S.Platelet-activating factor:receptors and signal transduction[J].Biochem J,1993;292(Pt 3):617-629.

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