Graves病患者外周血IL-6、TNF-α水平表达的变化及意义

The change of serum IL-6 and TNF-α levels in patients with Graves disease and its clinical significance

目的:探讨IL-6、TNF-α与Graves病(GD)发病之间的联系及其意义。方法:采用ELISA法测定83例GD患者治疗前后外周血IL6、TNFα水平变化,并与T3、T4、FT3、FT4、TSH作多元相关性分析。结果:(1)GD患者IL6、TNFα水平显著高于正常人(P<0.0001),且两者间呈正相关(P<0.001)。(2)IL6、TNFα与T3、T4、FT3、FT4均呈正相关(P<0.001),而与TSH呈负相关(P<0.001)。(3)经治疗后IL6、TNFα水平明显下降(P<0.001),但仍高于对照组(P<0.01)。结论:推测IL6、TNF异常升高可能与GD免疫学发病机制有关,经治疗后IL6、TNFα水平明显下降,提示抗甲状腺药物可能具有一定的免疫调节作用。

Objective： To explore the correlation between IL-6 and TNF-α and the pathogenesis of Graves Disease （GD）. Methods：Serum levels of IL-6 and TNF-α were measured by ELISA in 83 GD patients with pre- and post- the ArID threatment. The multiple correlation between Serum IL-6 and TNF-α and T3 ,T4, FT3, FT4, TSH in those patients were also analysised. Results： （ 1 ）The serum levels of IL-6 and TNF-αwere significantly higher in active GD patients than those of controls （P 〈 0. 000 1 ）. The positive correlation had been found between IL-6 and TNF-α（ P 〈 0. 001 ）. （2） Peripheral blood IL-6 and TNF levels in those patients had a positive correlation with T3 ,T4 ,FI3 ,FT4（P 〈0. 001 ）. And a negative correlation with TSH（P 〈0. 001 ）. （3） After ATD therapy the IL-6 and TNF-αdecreased significantly（ P 〈 0. 001 ） but were still higher than those of controls（ P 〈 0. 01 ）. Conclusion：Increased significantly levels of serum IL-6 and TNF-α might play a role in the immunopathologic of GD. After ATD treatment the serum levels of IL-6 and TNF-αremarkably decreased,which indicated that ATD might has some immune-regulation effects.