可促进神经再生的胶原蛋白中空湿法纺丝成形研究

Preparation and Wet-spinning of Collagen Hollow-fiber Membrane for Improvement of Nerve Regeneration

对牛胶原蛋白的可纺性及湿法中空成形进行了研究,探讨了胶原蛋白不同的制备工艺参数如pH值、温度、离子强度等对胶原蛋白可纺性的影响,并着重讨论了纺丝速度、填充液压力、致孔剂含量等纺丝工艺参数与胶原中空纤维膜性能及结构的关系。体外细胞实验的结果表明:该胶原蛋白对神经细胞的生长具有促进作用。

Preparation and wet-spinning of collagen hollow-fiber membrane for improvement of nerve regeneration has been investigated. The preparation parameters affecting the viscosity of collagen has been discussed, such as pH value, p spinning fiber has collagen. profile of speed, flow rate of fillin also been studied. In-vi osttreatment and time, temperature, gqiquid, percent of hole-forming reage tro bio-experiment, nerve regeneration In-vitro bio-experiment has indicated that such GRP-nerve cell. ion concentration. The effect of nt on the character and physics of has been greatly accelerated with formed collagen membrane has improved the