摘要
目的 对10680例患者使用丙泊酚注射液(静安注射液)全麻诱导期间不良反应的发生率进行了前瞻性、多中心调查。方法 全麻下择期手术的病人,术前未用药。以0.2mL/s的速度静脉注射丙泊酚,从开始注药至患者神智消失前,每间隔5~10S评测患者注射侧肢体有无疼痛反应及疼痛程度,同时观察记录兴奋、躁动的情况。结果 对10680例患者进行疼痛评分,其中无注射痛者6398例,轻度注射痛者3871例,中度注射痛者341例,重度注射痛者70例,疼痛发生率为40.09%;男性与女性疼痛的出现率分别为39.07%和40.59%(P=0.124);上肢和下肢注射痛发生率分别为57.6%和59.3%(P=0.468)。观察了7815例患者躁动情况,未出现躁动者7099例;出现者为716例,出现率为9.2%。对7192例患者观察了多语情况,出现多语者168例,出现率为2.3%。结论 注射痛是丙泊酚在麻醉诱导时最常见的不良反应,虽然中、重度疼痛的发生率较低,但仍应该采取预防措施。
Objective To investigate the incidence of adverse effects of propofol in large samples and multi-center epidemiological study. Methods The patients without premedication were induced with propofol at 0.2 mL/s with peripheral venous injection. The pain evaluation was performed every 5-10 s and restlessness and talkative were investigated until the patients losing consciousness. Results 10 680 questionnaires that recorded pain scale were received. The incidence of mild injection pain was 36.25 %, moderate pain was 3.19%, and severity pain was 0.66%. The total incidence of injection pain was 40.09%. The incidences of pain were not significantly different between male and female(P= 0. 124), or between venous injection from upper limb and lower limb(P= 0. 468). 7 815 questionnaires that surveyed restlessness and 7 192 questionnaires that surveyed talkative were received. The number of patients' occurrence restlessness and talkative were 716 and 168, respectively. The incidence of restlessness and talkative was 9.2% and 2.3%, respectively. Conclusion Injection pain is the most common adverse. The incidence of injection pain of propofol 1% fresenius injection was 40.09 %. Some measures should be taken to prevent the injection pain.
出处
《首都医科大学学报》
CAS
2006年第2期255-257,共3页
Journal of Capital Medical University