卵巢癌分型及其分子遗传学研究进展

Histological types and molecular genetical progress in ovarian carcinoma

卵巢癌是最常见的妇科恶性肿瘤之一,如何正确认识这类肿瘤一直备受关注。多年的病理形态学观察和临床病理资料积累,提示其各组织学亚型的生物学行为和发生、发展规律是有差异的。近年分子遗传学技术的应用为更客观的认识、诊断这类肿瘤和进一步指导患者的临床治疗、估价预后提供了新的研究方法和途径。本文对卵巢癌及其不同组织学亚型分子遗传学改变的研究进展进行综述。

Ovarian carcinoma is one of the most common and lethal gynecological malignancy, and the knowledge about its nature has always been concerned. Clincopathological data indicated that different histological subtypes had their own biological features, and were associated with distinct pathogenesis. Recently, technical application of molecular genetics has provided a new approach to histological diagnosis more objectively and further indicating clinical therapy and evaluating patients＇ prognosis. Here we review molecular genetic progress in each of histological subtypes of ovarian carcinoma.