凋亡抑制基因Survivin和抑癌基因PTEN在前列腺癌组织中的表达及临床意义

Expression and Significance of Survivin protein,PTEN in Prostatic Cancer

目的:研究凋亡抑制基因Survivin和抑癌基因PTEN在前列腺癌(PCa)中的表达及其与肿瘤病理分级、临床分期的关系。方法:应用免疫组化法,检测43例PCa和5例良性前列腺增生(BPH)组织中Survivin蛋白和PTEN的表达。结果:43例PCa组织中Survivin蛋白的表达率为81.40%,随PCa病理分级、临床分期的增高而增高。5例BPH组织中未见其阳性表达。PTEN蛋白在43例PCa组织中阳性表达率为30.23%,PTEN阳性表达率随肿瘤细胞病理分级、临床分期程度的增高呈下降趋势。5例BPH组织中PTEN蛋白均呈阳性反应。结论:Sur-vivin蛋白和PTEN的表达与PCa临床病理特征和生物学行为有密切关系,联合检测Survivin和PTEN,对诊断PCa、判断其恶性程度及预后均有一定参考价值。

Objective： To study the expressions of survivin , PTEN and their relationships with tissue grade and pathology stage in prostatic carcinoma（PCa）. Methods： The immunohistological staining was used to evaluated the expressions of survivin protein and PTEN in 43 case of prostatic carcinoma（PCa） and 5 cases of benign prostatic hyperplasia（BPH）. Results ： The positive rate of survivin. protein was 81.40%. Expression of survivin protein in 5 case of BPH was negative. The positive rate of PTEN was 30.23%, and the higher the grade and the clinical stage of tumors were, the lower the expression of PTEN was, PTEN of 5 case of BPH was positive. Conclusion ： The positively correlation was found between the abnormal expressions of survivin protein, PTEN and the biological behavior of prostatic carcinoma（PCa）. Detection of survivin combined with PTEN is valuable for diagnosing PCa, and evaluating malignancy extent and prognosis.