Patient with hepatocellular carcinoma related to prior acute arsenic intoxication and occult HBV:Epidemiological,clinical and therapeutic results after 14 years of follow-up

Little is known about the long-term survivors of acute arsenic intoxication. We present here a clinical case report of a man with chronic hepatitis B virus （HBV） infection who developed hepatocellular carcinoma four years after acute arsenic poisoning. HBsAg was detected in serum in 1990 when he voluntarily donated blood. In 1991, the patient suffered from severe psychological depression that led him to attempt suicide by massive ingestion of an arsenic-containing rodenticide. He survived with polyneuropathy and paralysis of the lower limbs, and has been wheelchair-bound since then. During participation in a follow-up study conducted among HBV carders, abdominal ultrasound detected a two-centimeter liver mass consistent with hepatocellular carcinoma. The tumor was confirmed by computed tomography （CT） and magnetic resonance image （MRI）. Because of his significant comorbidity, the patient received palliative treatment with transarterial lipiodol chemoembolization （TACE） on three occasions （1996, 1997 and 1999）. At his most recent visit in lay 2005, the patient was asymptomatic, liver enzymes were normal and the tumor was in remission on ultrasound.

很少对尖锐的砷沉醉的长期的幸存者被知道。我们在场这里在尖锐的砷毒害以后开发了肝细胞癌四年的有长期的肝炎 B (HBV ) 感染的一个人的一份临床的病案报告。HBsAg 在 1990 在浆液被检测他是否自愿地捐赠了血。在 1991，病人受不了导致了他由包含砷的减鼠剂的巨大的摄取尝试自杀的严重心理消沉。他与下肢的多神经病和麻痹幸存，并且从那以后是轮椅界限。在在在 HBV 搬运人之中进行的后续研究的参予期间，腹的超声检测了与肝细胞癌一致的一个二厘米的肝团。肿瘤被计算断层摄影术(CT ) 和磁性的回声图象(MRI ) 证实。因为他的重要 comorbidity，病人与 transarterial 碘油 chemoembolization 收到了矫形疗法(不作声) 在三个场合(1996， 1997 和 1999 ) 上。在他在 2005 年 5 月的最近的访问，病人是无征状的，肝酶是正常的，肿瘤在超声上的宽恕。