大鼠异体神经段皮下包埋的形态学研究

Nerve in subcutaneous compartment: an experimental morphological study

目的研究大鼠异体神经段经皮下包埋2周的形态学变化。方法W istar大鼠30只,雄性。C组(10只)为供体组,余随机分为2组,实验(A组)组10只,于右大腿后侧皮下行异体坐骨神经包埋,2周后取出;对照组(B组)10只,取左坐骨神经15mm包埋于右大腿后侧,2周后取出,行形态学研究。结果实验组炎性反应稍重于对照组,髓鞘退变2组相似。结论A组周围神经发生一定的炎性反应,但schwanncell(SC)的活性与B组周围神经相似。

Objective To study the ultrastructural changes of cell in a subcvtaneous implant of peripheral nerve in rats. Methods Thirty male wistar rats were divided into 3 groups （ A, B, C groups）. There were 10 rats in each group,Group C served as the donors. A 15mm segment of sciatic nerve harvested from the donors was sepa- rately inserted into subcutaneous compartment on the fight thigh in the rats of group A. In the control group（ group B,n = 10） ,a 15mm segment of sciatic herve harvested from the left thigh,and was inserted into subcutaneous compartment on the right thigh. Two weeks later,the segment of sciatic nerve in subcutaneus compartment was removed en bloc for morphological observation. Results The inflammatory reaction was stronger in group A than that of group B. The degeneration of tendinous sheath was the same both in group A and group B. Conclusion The allograft of sciatic nerve inserted into subcutaneous compartment can promote inflammatory reaction, but Schwann cell of the allograft was the same as that of the autograft.