P300监测对奥拉西坦治疗轻型脑伤的疗效观察

Treatment effects of Oxiracetam on mild brain injury by P300 monitoring

目的通过对事件相关电位P300的监测,评价益智药奥拉西坦治疗轻型脑伤的疗效。方法采用随机双盲阳性药物对照试验,试验组与对照组各24例。分别于用药前、用药21天后进行P300数据采样,然后对2组用药前后的数据进行配对t检验,以分析用药前后的P300差异;对2组用药前后的P300差值进行2样本t检验,以分析差异。结果2组患者用药前后的P300参数均有差异(P<0.05),即2种药物对患者的P300改善均有效;2组患者用药前后的P300参数差值有差异(P<0.05),即试验组较对照组效果更为明显。结论奥拉西坦对轻型脑伤的认知改善有明显促进作用,且功效较对照药更强。

Objective To assess the effects of Oxiracetam on mild brain trauma by P300 monitoring. Methods The random double-blind contrast test was taken. The contrast medicine was Piracetam injection. Both the Piracetam group and Oxiracetam group contained 24 cases. We collected the data of P300 before giving medicine and after 21 days（ the end of treatment）. Then the difference of the data of P300 between the beginning and the end of giving Piracetam and Oxiracetam were analyzed by paired t-test. The difference of the discrepant data of P300 between piracetam group and oxiracetam group will be analyzed by two-sample t-test. Results The discrepancy of the data of P300 between the beginning and the end of giving the 2 medicines was proved to be existent （ P 〈 0.05 ） , which showed that the 2 medicines were beneficial to the improvement of the patients＇ cognitive ability. The difference of the discrepancy of the data of P300 between the 2 groups was present （ P 〈 0. 05 ） , which showed that the effect of Oxiracetam group was more obvious than that of Piracetam group. Conclusion Oxiracetam can distinctly improve the cognitive ability of mild brain trauma cases, and the efficacy of which is better than Piracetam.