聚明胶肽治疗创伤失血性休克的临床观察

Clinical observation of Polygeline injection treatment for traumatic hemorrhagic shock

目的观察聚明胶肽注射液对中、重度创伤失血性休克患者的血压和微循环影响。方法选择中、重度创伤失血性休克患者80例,随机分为聚明胶肽注射液组和4%琥珀酰明胶组,每组40例。抢救时除采用止血、扩充血容量、纠正酸碱平衡紊乱等综合措施外,分别输入聚明胶肽注射液和4%琥珀酰明胶15m l/kg。两组均监测血压、尿量、血气分析,比较两组指标恢复正常及末梢循环改善所需的时间。结果聚明胶肽组与4%琥珀酰明胶组上述指标恢复正常及末梢循环改善所需的时间差异无显著性,两组生存率、致残率及并发症均无显著差异。结论聚明胶肽注射液用于中、重度失血性休克对稳定血压和改善微循环与4%琥珀酰明胶的作用相似。

Objective To observe the influence of Polygeline injection on the blood pressure（ BP） and microcirculation of moderate and advanced hemorrhagic shock. Methods Eighty patients with hemorrhagic shock were randomly divided into treatment group （ Polygeline injection group） and control group（ Gelofusine group） ,with 40 cases in each group. The same measures such as hemstasis,expanding blood volume,correction of acid base disturbance and so on were adopted in the both groups. The patients in the treatment group and control group were respectively treated with Polygeline injection and Gelofusine in a dose of 15 ml/kg by intravenous infusion. The time from injection to the recovery of BP, urinary output, blood gas and distal circulation to normal level was recorded. Results BP, urinary output, blood gas and distal circulation were all improved significantly, there was no significant difference between the two groups （P 〉0.05 ）. Conclusion The curative effect of Polygeline injection on stabilizing BP and improving microcireulation appears comparable to that of Gelofusine.