实验性呼吸窘迫综合征时红细胞和白细胞变形能力改变及其与肺血流阻力的关系

THE CHANGES OF RED AND WHITE BLOOD CELL DEFORMABILITY AND ITS RELATION TO THE PULMONARY FLOW RESISTANCE DURING EXPERIMENTAL RDS

实验性呼吸窘迫综合征犬油酸模型的红细胞和白细胞变形能力以及静注油酸后２４０ｍｉｎ内（０，３０，６０，１２０和２４０ｍｉｎ５个时点）肺血流阻力的动态变化，发现肺血流阻力进行性增加（由基础值３５．５±７．０ｋＰａ．ｓ／Ｌ增至２４０ｍｉｎ时９５．５±２６．５ｋＰａ．ｓ／Ｌ，Ｐ＜０．０１），红细胞和白细胞变形指数分别由基础值０．３６±０．０８，４．１０±０．７５升为２４０ｍｉｎ时０．６２±０．２２，６．９１±１．４４（Ｐ＜０．０１），即红细胞和白细胞变形能力显著降低。单因素直线回归分析示肺血流阻力与红细胞和白细胞变形能力呈负相关。

The present work reports the changes of pulmonary flow resistance,and the deformability of red and white blood cells during experimental respiratory distress syndrome induced by oleic acid in dogs.It was found that pulmonary flow resistance increased progressively, the deformability of red blood cells and white blood cells decreased obviously from 60 min and 120 min after oleic acid infusion respectively. The analysis of liner regression on the pulmonary flow resistance and the deformability of red and white blood cells suggested that the increase of pulmonary flow resistance had close relation to the decrease of deformability of red blood cells and white blood cells.