摘要
目的:通过研究养血清脑颗粒对自发性高血压大鼠(SHR)循环和肾组织局部RAS活性的影响,探讨其作用机制和靶点。方法:60只SHR大鼠随机分为模型组,卡托普利组,牛黄降压丸组,养血清脑颗粒高、中、低剂量组,共6组,同时选取10只WHY大鼠作为对照组。给药8w后,用仪器SN-695B型放免γ测量仪以放免的方法测定血浆和肾脏组织内血管紧张素Ⅱ(AngⅡ)、醛固酮(Ald)。结果:使用各组药物后,肾组织血管紧张素-醛固酮系统变化显著,养血清脑颗粒中剂量组AngⅡ含量和模型组相比有显著差异,P<0.001;高剂量组、低剂量组和模型组相比,也有显著性差异P<0.05。养血清脑颗粒高、中剂量组醛固酮含量比模型组明显降低。结论:养血清脑颗粒很可能是通过在肾组织内血管紧张素-醛固酮系统发挥其降压作用和肾脏保护作用的。
Objective:To Observe the effect of Yangxue Qinnao grain on plasma and kidney tissue renin-angiotensin system ( RAS ) of spontaneously hypertensive rats ( SHR ). Methods: 60 SHR were randomized into modle group, Captopril treatment group, Niuhuang Jiangya pill treament group, Yangxue Qinnao treatment group 1 ( high dosage ), group 2 ( medium dosage ), group 3 ( low dosage ). 10 WKY rats were regarded as normal group. After 8 weeks treatment, Ang Ⅱ and Aid were determined. Results:Yangxue Qingnao grain can reduce the level of the angiotensin Ⅱ not only in plasma but also in kidney. Conclusion:Yang xue Qingnao grain can reduce the blood pressure and protect the kidney,it's mechanism maybe is through it's renin-angiotensin system in kidney.
出处
《山西中医学院学报》
2006年第2期9-10,共2页
Journal of Shanxi College of Traditional Chinese Medicine
基金
国家"十五"攻关项目(项目编号:2001BA701A07-30)