急性热应激对飞行员淋巴细胞DNA损伤的研究

Study on the Effect of Acute Heat Stress on the Lymphocytic DNA Damage of Pilot

我们用单细胞凝胶电泳检测技术探索了急性热应激对飞行员淋巴细胞ＤＮＡ损伤的影响，结果发现，急性热应激使飞行员淋巴细胞ＤＮＡ损伤发生率增高，损伤程度加重。同时我们分析了现有疾患与淋巴细胞ＤＮＡ损伤之关系，发现其现患疾患的飞行员ＤＮＡ损伤发生率明显增高。本结果提示了淋巴细胞ＤＮＡ损伤可能作为评价飞行员停飞的辅助指标。

The effect of acute heat stress on the lymphocytic DNA damage of pilot was studied with single cell gel electrophoresis assay,The study showed that acute heat stress could increase the occurance rate of lymphocytic DNA damage of pilot and aggravate the damage degree of lymphocytic DNA. The analysis of the DNA damage of lymphocyte and the present diseases in pilots further showed that the occurrance rate of the DNA damage of lymphocyte in pilots with some diseases was higher than that of healthy pilot(P<0.05).These results suggested that DNA damage of lymphocytes might be considered as a supplementary index for the evaluation of pilot′s health condition.