绝经与子宫内膜癌预后的关系

The Relationship between Menopausal State and Prognosis of Endometrial Cancer

目的探讨绝经前后妇女子宫内膜癌的临床病理特征以及绝经能否作为子宫内膜癌的预后因素。方法将212例子宫内膜癌患者按是否绝经分为2组:未绝经组78例,绝经组134例。分析两组患者的临床病理特征及预后。结果未绝经组与绝经组相比,不孕患者比例低(分别为14.1%和19.2%),高血压患者比例低(分别为4.5%和33.6%),组织分级低(G3分别为12.3%和26.2%)、深肌层浸润少见(分别为9.0%和29.1%),复发少(分别为5.1%和12.7%),生存率高。上述各项均有显著性差异(P<0.05)。结论未绝经子宫内膜癌者的预后较好,与临床病理特点有关。绝经可以作为子宫内膜癌的1个独立的预后因素。

Objective The purpose of our study was to study the clinical and pathologic characteristics of 212 patients with endometrial cancer and examine the menopausal state as an independent prognostic variable of endometrial cancer, Methods We divided the patients into two groups according to the menopausal state. Each group has 78 and 134 patients, respectively. Then we studied the clinical and pathologic variables of the two groups. Results When the premenopausal group was compared with the postmenopausaul guroup, the rate of eases with infertility was lower （14.1% and 19.2%, respectively）, the rate of cases with hypertension was higher （4.5% and 33.6%, respectively）, the tumor grade was lower （G3 was 12.3 % and 26.2 %,respectively）, the deep myometrial invasion was less （9.0% and 29.1%, respectively） with less recurrence （5.1% and 12.7%, respectively）, and higher survival rate. The differences were significant in all the aspects mentioned above （P 〈 0.05）. Conclusion The clinical and pathologic characteristics of endometrial cancer might be responsible for the better prognosis of premenopausal patients compared with postmenopausal ones. The menopausal state was an independent prognostic variable for patients with endometrial cancer.