乐沙定联合亚叶酸钙及5-氟尿嘧啶治疗晚期胃癌的临床观察

Efficacy of Eloxatin Combined with 5-Fluorouracil(5-Fu) and Calcium Folinate(CF) in Treatment of Patients with Advanced Gastric Cancer

目的观察革酸铂（L—OHP），（商品名为乐沙定）联合亚叶酸钙（CF）及5-氟尿嘧啶（5-Fu）持续静脉输注治疗晚期胃癌的临床疗效。方法乐沙定85mg/m^2静脉点滴2-3h，d1。CF200mg/m^2，静脉输洼2小时；5-Fu 400mg/m^2,静脉推注。后再以5-FU600mg/m^2持续静脉滴注泵连续泵入22h，d1．d2，每2周重复。完成至少3个周期后评价疗效。结果接受治疗的32例病例均可评价疗效。CR 1例（3．1％），PR14例（43．8％），总有效率（CR＋PR）46．9％（15／32）。肿瘤中位进展期6．8个月；中位生存期8．6个月。主要毒副反应为：恶心、呕吐、外周神经毒性，骨髓抑制，黏膜炎和静脉炎等。无因毒副反应而终止治疗者，无化疗相关死亡。结论FOLFOX4方案治疗晚期胃癌近期疗效确切，毒副反应较轻，值得临床进～步推广研究。

Objective Toevaluate the clinical efficacy and toxicity of eloxatin （L-OHP） plus 5-FU/CF in treatment of patient with gastric cancer. Methods Thirty-two patients with advanced gastric cancer entered the study, the patients received L-OHP 85 mg/m^2（ivdrip 2-3 h） dl;CF 200 mg/m^2（ivdrip,2 h） dl and d2,5-Fu 400 mg/m^2（iv,bolus） and 5-Fu 600 mg/m^2（22 h continuous iv with pump）, dl and d2. The treatment every 2 week as a circle. The efficacy was evaluated after at least 3circles, Results All patients could be evaluated. There were 1 CR （3.1% ） and 14 PR （43.896 ） ; the overall response rat was 46.9 % ; the TTP was 6.8 months and the MST was 8.6 months. Main toxic reactions were nausea/vomiting, mucositis, neurousensory toxicity, neutropenia and peripheral phlebitis. Conclusion Eloxatin combined with 5-Fu/CF shows better efficacy and tolerable toxicity.