原发性肺腺癌危险因素性别差异分析

A COMPARISON OF RISK FACTORS FOR PRIMARY PULMONARY ADENOCARCINOMA DUE TO SEX DIFFERENCE A CASE CONTROL STUDY.

为分析不同性别原发性肺腺癌的危险因素，本文对南京市１８０例（男性１００例，女性８０例）原发性肺腺癌进行了配对病例对照研究。条件Ｌｏｇｉｓｔｉｃ多因素模型分析结果表明，烹调油烟污染、慢性支气管炎疾患史、肿瘤家族史等为男女性别肺腺癌发生的共同危险因素。其相对危险度（ＲＲ）对男性分别为２．８４、２．３０、４．８９。对女性分别为３．２０、３．２３、４．２３，另外，男性肺腺癌的发生尚与吸烟有关，ＲＲ为１．０１，女性肺腺癌的发生则与冬季煤炉采暖有关，ＲＲ为２．２９。本文尚分别对各危险因素进行了人群归因危险度的估计。

To examine risk differences in primary pulmonary adenocarcinoma due to sex difference,this case control study compared 180 cases(100 males,80 females) of primary pulmonary adenocarcinoma in Nanjing.By multivariate analysis using the conditional logistic regression model,cooking fume pollution,chronic bronchitis,and family tumor history were found to be common risk factors for adenocarcinoma in the lung for both sexes.The respective relative risks (RR) were:for men 2 84(95%CI=1 74-6 52),2 30(95%CI=1 03-5 15),4 89(95%CI=1 41-16 97);for women 3 20(95%CI=1 40-7 30),3 23(95%CI=0 87-12 03),4 23(95%CI=1 02-17 45).The respective population attributable risks (PAR) were:for men 0 4278,0 2036,0 1750;for women 0 5241,0 1468,0 1909.The occurrence of male pulmonary adenocaroinoma was related also to smoking,with RR of 1 01(95%CI=1 00-1 03),PAR of 0 2769.The ocurrence of female pulmonary adenocarcinoma was found to be related to heating by coal stove,with RR of 2 29(95%CI=0 95-5 50),PAR of 0 1759.