摘要
目的:探讨颞下颌关节紊乱病(TMD)患者关节液中基质金属蛋白酶-3(MMP-3)与关节病变程度的关系。方法:留取115例TMD患者符合标准的126侧关节和健康志愿者32侧关节关节液标本。患者标本依据临床和TM J影像学检查,分为①关节炎症性疾病(C/S)组(n=24);②结构紊乱(ID)组(n=58);③骨关节病(OA)组(n=44);④健康志愿者关节液设为对照组(n=32)。用ELISA法检测关节液标本中MMP-3含量。结果:OA组MMP-3含量为(74.677±46.910)ng/m l(32/44),ID组为(49.086±22.298)ng/m l(20/58),C/S组为(32.609±9.470)ng/m l(7/24),对照组含量为(23.663±8.767)ng/m l(14/32)。OA组、ID组与C/S组及对照组比较有显著差异(P<0.05);ID组、C/S组与对照组比较亦有显著差异(P<0.05)。结论:MMP-3直接参与了TM J关节组织的病理破坏过程;关节液中MMP-3的水平反映了TMD病变的严重程度;关节液中的MMP-3可以作为一个反映TMD关节损害和代谢的重要分子标志。
Objective :To investigate the relationship between the concentration of matrix metalloproteinase-3 (MMP-3) in synovial fluid and the degree of tissue lesion in TMJs from patients with TMD. Methods:Samples from 126 TMJs in TMD patients were divided into three groups according to clinical examination and imaging findings : ① Capsulitis/Synovitis (C/S) group ( n=24 ) ; ②Internal derangement (ID) group (n = 58 ) ; ③ Osteoarthritis (OA) group (n=44). ④Samples from asymptomatic volunteers served as control group (n=32). The concentration of MMP-3 in TMJ synovial fluid was measured using Enzyme-linked -immunosorbent-assay (ELISA). ResuIts: The level of MMP-3 in OA group (74. 677±46. 910)ng/ml, was significantly higher than that in ID group (49. 086±22. 298 )ng/ml, C/S group (32. 609±9. 470)ng/ml and control group (23.663±8.767 )ng/ml ( P 〈 0.05 ). Both the levels of MMP-3 in ID group and C/S group were significantly higher than that in control group (P〈0.05 ). ConcIusion: MMP-3 was involved in the pathogenesis of TMD. The level of MMP-3 in synovial fluid could reflect the degree of lesion of TMJs.
出处
《华北国防医药》
2006年第2期92-94,共3页
Medical Journal of Beijing Military Region
基金
北京军区"十五"医学科学技术研究资助项目(No.02B011)