新生儿先天性甲状腺功能低下症筛查及治疗效果分析

The analysis of effect of treatment and screening of neonatal congenital hypothyroidism in Henan province

目的:探讨河南省新生儿先天性甲状腺功能低下症(CH)的筛查状况及治疗效果和由此产生的效益。方法:采用时间分辨免疫荧光法检测标本中促甲状腺素(TSH)水平,筛查阳性者召回,用直接化学发光免疫分析法测定静脉血清中T3、T4、TSH浓度,T3、T4值低于正常,TSH浓度高于正常者确诊为患儿,根据其出生年龄和体重立即口服甲状腺素片治疗并进行疗效评估和效益分析。结果:掌握了河南省新生儿CH的发病率和群体分布规律,肯定了开展筛查治疗的效果及产生的效益。结论:开展新生儿甲状腺功能低下症的筛查及治疗能降低患儿的致残率,并能取得显著的经济和社会效益。

Objective： To investigate the screening state of neonatal congenital hypothyroidism in Henan Province and its benefits. Methods： The levels of thyroid - stimulating hormone （TSH） were measured by time - resolved fluoroimmunoassay, positive newbores were recalled.to detect the serum levels of TSH, triiodothyronine （T3 ） and thyroxine （ T4 ） by direct chemil The abnormal criterion was that the level of T3, T4 under the normal range and the level of TSH above the normal range. The newborns with congenital hypothyroidism were treated with thyroxine by their age and weight. Results： The incidence and group distributive regularity of congenital hypothyroidism was established to verify effect of treatment and screening. Conclusion： The paralysed rates of children with congenital hypothyroidism were decreased by early screening and treatment, having remarkably social and economical effect.