早期应用低分子肝素钙预防危重儿DIC的临床研究

Clinical study of low molecular weight heparin therapy used early in prevention of DIC in critically ill children

目的:采用低分子肝素钙早期预防危重儿D IC评价其疗效。方法:将43例危重患儿作为研究对象,随机分为2组,治疗组23例,早期应用低分子肝素钙10 g/kg皮下注射,2次/d,连用3 d。对照组21例,不予低分子肝素钙预防,两组的其他治疗原则相同,观察两组病例出现D IC发生率及死亡率比较。结果:治疗组出现D IC发生率较对照组明显降低(P<0.01),死亡率较对照组明显降低(P<0.01),两组具有显著性差异。结论:早期应用低分子肝素钙能有效地预防危重儿D IC出现,并能降低危重儿死亡率。

Objective： To investigate the therapeutic effect of low molecular weight heparin （LMWH） therapy in critically ill children to prevent disseminated intravascular coagulation （DIC）. Methods： Forty - three severe patients were randomly divided into routine treatment group （n = 22, given LMWH early, twice a day for 3 days, except routine treatment） and control group （n = 21, routine treatment）. The prevalence of DIC and mortality in two groups were observed and compared. Results： Incidence of DIC and mortality in treatment group were significant lower than those in control group （P〈0.01 ）. Conclusion： LMWH was applied early in severe patients, which could not only prevent efficiently DIC, also diminish mortality.