华北地区2003年流动人口麻疹抗体水平及其影响因素分析

Analysis of Measles Antibody Levels Among Floating Population in Five Provinces of North China in 2003

目的了解华北地区2003年流动人口麻疹抗体水平及其影响因素。方法华北地区5个省（自治区、直辖市．下同）共送检血清标本646份，采用酶联免疫吸附试验（ELISA）检测麻疹IgG抗体。结果麻疹抗体总阳性率为95．4％，几何平均倒数滴度（GMRT）为1974．5。不同年龄组、不同省、不同免疫史人群麻疹抗体阳性率差异无显著的统计学意义；但小年龄组（20～24岁）与高年龄组（≥30岁）、有免疫史与无免疫史人群麻疹抗体GMRT差异有显著的统计学意义。疫苗免疫和自然感染产生的麻疹抗体水平差异可能是导致这一现象的主要原因。结论流动人口尤其是小年龄组人群纳入计划免疫管理对控制麻疹有重要意义。

Objective To find out the levels and factors influencing measles antibody of floating population in five Provinces. Methods 646 samples of sera from Beijing, Tianjin, Hebei, Shanxi and Inner Mongolia were tested by ELISA to evaluate measles antibody levels with five grades of negative, 1 ： 200,800,3200 and 12800. Results The positive rate of measles antibody in floating population was 95.4 % and the GMRT was 1974.5. There are no significant differences in seropositive rate of measles antibody among different age groups, provinces groups and immune history groups. However, the GMRTs were significant difference between 20 - 24 age group and ≥30 age group, as well as between group with and without immune history. This may due to the different levels of measles antibody stimulated by vaccine and naturally infection. Conclusion To include the floating population, especially young children, into the measles planed immunization management in urban areas is most important for the measles control program.