绝经后女性脑梗死患者血清垂体促性腺激素、催乳素的检测及其意义

SIGNIFICANCE OF SERUM PITUITARY GONADOTROPIN AND PROLACTIN IN POSTMENOPAUSAL WOMEN WITH CEREBRAL INFARCTION

目的探讨血清促卵泡刺激素(FSH)、黄体生成素(LH)及催乳素(PRL)在绝经后女性脑梗死患者发病过程中的变化特点及其意义。方法采用放免法动态测定110例绝经后女性脑梗死患者血清FSH、LH及PRL的水平。分析其与病程、病情、梗死范围及梗死部位的关系。结果①绝经后女性脑梗死患者急性期血清FSH、LH值下降,PRL值升高,与恢复期及对照组比较,差异有统计学意义(P<0.01);恢复期血清FSH、LH及PRL值与对照组比较,差异无统计学意义(P>0.05)。②急性期中、重型组血清FSH、PRL值明显高于轻型组(P<0.05),二组间血清LH差异无统计学意义(P>0.05)。③梗死范围≥2cm×2cm×2cm组血清PRL明显高于梗死范围<2cm×2cm×2cm组(P<0.05);二组间血清FSH、LH差异无统计学意义(P>0.05)。④急性期皮质组、皮质下组、混合组比较,血清FSH、LH及PRL值差异无统计学意义(P>0.05)。结论绝经后女性脑梗死患者急性期存在垂体促性腺激素(FSH、LH)及PRL的紊乱,而随着疾病的恢复趋于正常。且这种紊乱不受梗死部位的影响,除PRL外也不受梗死范围影响,而与病情程度密切相关。

Objective To study change Characters and significances of serum pituitary gonadotropin and prlactin in postmenopausal women with cerebral infarction. Methods Serum levels of folliclestimulating hormone, luteinizing hormone and prolactin were dynamic tested by radioimmunoassay （RIA） in 110 postmenopausal women with cerebral infarction. The relationship between the changes of these hormones and the courses, conditions, sizes and locations of infarction were analyzed. Results ①The serum levels of FSH and LH decreased,that of PRL increased in acute stage of postmenopausal female cerebral infarction patients, it had remarkable difference from those of convalescent stage and control subjects（P〈 0.01）. There was no significant difference between convalescent stage and control subjects in serum levels of these hormones （P〉0.05）. ②Serum levels of FSH and PRL of acute patients were significant higher in middle type and severe type groups than those in slight type group（P 〈0. 05）. There was no difference between the two groups in serum levels of LH （P〉 0.05）. ③Serum level of PRL was higer in infarction volume≥2cm × 2cm × 2cm patients than those in infarction volume〈 2cm × 2cm × 2cm patients. There were no significant difference between the two groups in serum levels of FSH and LH. ④There were no significant difference among cortical infarction group, subeortieal infarction group and complex infarction group of postmenopausal women with cerebral infarction in serum levels of FSH, LH and PRL（P〉0.05）. Conclusion There are disorders of pituitary gonadotropin and prolaetin in postmenopausal women with acute cerebral infarction , the disorders tend to normalize stroke recover, and they are not associated with infarction size, but closely associated with the severity of stroke.