替米沙坦对老年收缩性高血压左心室舒张功能的影响

Effect of telmisartan on left ventricular diastolic function in isolated systolic aged hypertension

目的研究血管紧张素Ⅱ受体拈抗剂替米沙坦对老年收缩期高血压左心室舒张功能的影响。方法采用自身对照开放试验方法，56例原发性收缩期高血压伴左心室舒张功能不全的老年患者口服替米沙坦80～160mg，1次／d，治疗12个月后，对治疗前后进行超声多普勒左心舒张功能测量与对照分析。结果与治疗前相比，56例高血压患者治疗12个月后，血压显著下降（P〈0．01）；超声多普勒对照检查显示，左室后壁舒张末期厚度（LVPWT）、室间隔舒张末期厚度（IVST）、峰值充盈速度A、峰值速度A／峰值速度E比值均明显下降（P〈0．01）。结论替米沙坦在降压的同时，能有效地改善左心室舒张功能。

Objective To study the effect of telmisartan on left ventricular diastolic function in aged hypertentsive patients. Methods Fifty - six patients with left ventricular diastolic dysfunction were given 80 - 160rag telmisartan per day for 12 months. Ultrasonic scanning was performed in all patients and the results were compared before and after telmisartan treatment. Results After 12 months treatment with telmisartan, blood pressure was significantly decreased（ P 〈0.01 ）. Ultrasonic scanning indicated that LVPWT,IVST,A peak and A/E indexes were all decreased with sgnificant difference（ P 〈0.01 ）. Conclusion Telmisartan may not only decrease blood pressure, but also reserve the left ventricular hypertrophy and improve the left ventricular diastolic function at the same time.