摘要
目的探讨新生儿严重感染早期诊断快速、可靠的方法和测定降钙素原(PCT)在新生儿严重感染中的临床意义。方法对我院新生儿科的121例新生儿进行PCT、C反应蛋白(CRP)、白细胞介素6(IL-6)的测定,分为重症感染、局部感染和非感染3组进行分析。结果重症感染时,血清PCT、CRP和IL-6浓度均明显升高,与局部感染组和非感染组比较差异均有统计学意义(P<0.01)。结论PCT在新生儿严重细菌感染早期即升高,可作为新生儿重症感染早期诊断的标志物,PCT的动态变化可作为严重感染预后的指标,持续升高提示预后差。
Objective To investigate the early and reliable diagnostic method and the clinical significance of procalcitonin （PCT） in neonates with serious infection. Methods PCT was detected in 121 neonates in our hospital＇s neonates department, then compared with CRP and IL -6. According to the result, the patients were divided into three groups：serious infection group, local infection group, non- infection group. Results PCT, CRP, IL- 6 level in blood significantly increased in serious infection group ,and had statistical significance compared with local infection group and non -infection group （ P 〈 0.01 ）. Conclusion PCT can be used as an early diagnostic index for serious infection in neonate. Dynamic study of PCT can be used as symbol of serious infection prognosis. Persistent elevate of PCT infers bad prognosis.
出处
《临床医学》
CAS
2006年第4期66-67,共2页
Clinical Medicine
基金
温州市科技局科研基金资助项目(编号Y2003A118)
