三种抗惊厥药物预防动物热性惊厥的比较研究

Comparison of Preventive Effects of Topiramate, Valproate and Phenobarbital on Febrile Conrulsion in Rats

目的动态观察大鼠药物干预后反复热性惊厥(FC)发生情况,探讨抗惊厥药物预防动物FC的疗效及其差异。方法 SD大鼠78只,用热水浴法制备反复FC大鼠模型。分为妥泰(TPM)组、苯巴比妥(PB)组、丙戊酸钠(VPA)组、生理盐水对照组。实施药物干预的同时,每两天使大鼠FC一次,记录大鼠对惊厥敏感程度的改变情况。结果大鼠用药后,药物处理组较对照组发生惊厥的潜伏期显著延长(F=4．2,P<0．01),惊厥持续时间显著缩短(F=28．2,P<0．01),惊厥严重程度显著减轻(F= 21．4,P<0．01)。其中,TPM组惊厥持续的时间较VPA组、PB组显著缩短(q=3．8、3．0,P<0．05),TPM组和PB组的惊厥发生的程度较VPA组显著减轻(P<0．05)。结论妥泰、丙戊酸钠和苯巴比妥都具有预防动物FC的作用,其中以妥泰的预防效果最好。

Objective To explore the preventive effects of topiramate （ TPM ） , phenobarbital （ PB ） and valproate （VPA） on febrile convulsion. Methods Seventy - eight Sprague - Dawley （ SD ） rats were randomly divided into control , TPM - treated, VPA - treated and PB - treated groups. Febrile convulsions were induced every other day by hyperthermal bath at 45℃. The different drugs were orally administered to the rats of different groups twice a days for 5days,and then once again immediately before each hyperthermal bath. The manifestations of febrile convulsions were observed in all the groups. Results The incubation period of the febrile convulsion was signficantly longer, the duration of the convusion was significantly shorter and the convusion was significantly alleviated in all the experimental groups compared with the control group （ P 〈 0.05 ）. The duration of convulsion were significantly shorter in TPM - treated group than that in VPA - treated group and PB - treated （ P 〈 0.05 }. The convulsion were significantly alleviated in TPM - treated and PB - treated groups compared to VPA - treated group （ P 〈 0.05 ）. Conclusions Continuous administration of three antiepilepsy drugs is of preventive effect on the febrile convulsion. Among them ,TPM was likely the best for preventing the febrle convulsion.