GSTM1基因多态性和膀胱癌遗传易感性关系

Genetic polymorphisms of GSTM1 and susceptibility to bladder cancer

目的:探讨谷胱甘肽转移酶(GSTM1)基因多态性与膀胱癌遗传易感性的关系。方法:采用面访填写调查表,以PCR技术、病例对照研究方法,对252例病理证实原发膀胱移行细胞癌患者和320例健康对照者的GSTM1基因型进行检测。结果:膀胱癌患者GSTM1缺失基因型频率为45.2%,对照组为30.9%,两组比较差别有显著性意义(P<0.05),OR值为1.89(95%CI=1.28～4.40)。吸烟者中,患者组GSTM1缺失基因型频率为66.2%,对照组为27.3%,差别显著(P<0.01),OR值为8.9(95%CI=5.36～14.82)。同时憋尿及有家族肿瘤史也能增加患膀胱癌的危险性,但多饮牛奶则能降低膀胱癌的危险性,而水果摄入多少与膀胱癌发生危险性无统计学意义。结论:GSTM1基因多态性与膀胱癌易感性有关,该基因多态性与吸烟在膀胱癌的发生发展中起协同作用。

Objective：To study the association between genetic polymorphisms of glutathione-S-transferases mu （GSTM）1 and susceptibility to bladder cancer. Methods.. We obtained information on demographic factors,medical history,lifetime of tobacoo smoking and alcohol drinking, and occupational exposures by a personal interview. In a case control study,252 patients with primary bladder transitional carcinoma proved by pathological examination and 320 age- and sex-matched controls were included. The GSTM1 genotype was determined by PCR. Results：The frequency of GSTM1 null genotype was 45.2% in the bladder cancer patients and 30.9% in controls （OR= 1.89,95%CI= 1.28-4.40）. The difference was significant （P〈0.05）. In smokers, the frequency of GSTM1 null genotype was 66.2% in the bladder cancer patients and 27.3% in controls （OR=8.9,95%CI= 5.36-14.82）. The difference was significant （P〈0.01）. The risk of bladder cancer increased in subjects with the habit of compulsive urinary retention and the family history of cancer. Milk intake decreased the risk of bladder cancer. There was no statistical significance between the intake of fruit and the risk of bladder cancer. Conelusion：GSTM1 polymorphisms are associated with susceptibility to bladder cancer. It has the synergistic effects with smoking in the development of bladder cancer. Bladder neoplasms;