抗心律失常肽与慢性心脏疾病的关系

Relationship between antiarrhythmix peptide and chronic heart diseases.

目的探讨慢性心律失常发生的常见疾病,如风湿性心脏病心房颤动、冠心病频发室性期前收缩及慢性心力衰竭患者血清中抗心律失常肽(AAP)含量的变化。方法采用高效液相法,利用高效液相色谱仪测定190例患者血清中AAP含量,并与正常同龄人血清中AAP含量比较。结果风湿性心脏病心房颤动、冠心病频发室性期前收缩、慢性心力衰竭患者血清AAP含量明显低于正常组(P<0.001)。结论风湿性心脏病、冠心病、慢性心力衰竭都可造成血清中AAP含量下降,这可能是易诱发心律失常的原因之一。

Objective To study the changes of the content of antiarrhythmic peptide （AAP） in chronic heart diseases （ such as atrial fibrillation of rheumatic valvular heart disease,frequent ventricular extrasystoles of coronary heart disease, and chronic heart failure）. Methods The contents of AAP in 190 patients were measured by HPLC and were compared with that of control group. Results The contents of AAP in atrial fibrillation group, in frequent ventricular extrasystoles group and in chronic heart failure group were all lower obviously than those of control group （P 〈 0.001 ）. Conclusion The reduced content of AAP in patients with atrial fibrillation of rheumatic valvular heart disease, frequent ventricular extrasystoles of coronary heart disease, and chronic heart failure may be one of the causes for complicated arrhythmia.