小剂量肝素联合5-FU治疗重症急性胰腺炎的研究

The effect of small dosage of heparin and 5-FU on patients with severe acute pancreatitis

目的探讨小剂量肝素联合5-FU对重症急性胰腺炎的临床治疗价值。方法将21例重症急性胰腺炎(SAP)患者随机分为2组:A组用小剂量肝素联合5-FU治疗,B组用生长抑素治疗,观察各组临床治愈时间、并发症发生率和病死率,及临化全项、CT等作动态检查。结果A、B组的临床治愈时间分别是48d、44d,并发症发生率分别是70%、73%,病死率分别是10%、9%。A、B二组差异无统计学意义(P>0.05)。结论小剂量肝素联合5-FU治疗SAP疗效肯定。

Objective To study the clinical value of the treatment 5 - FU and small dosage heparin on severe acute pancreatitis （SAP）. Methods Twenty - one patients with SAP were divided randomly into two groups ：group A ：SAP treated with small dosage heparin combined with 5 -FU;group B：with growth inhibitor. Clinical recovery time,complication rate,fatality rate were observed and clinical chemistry and CT were studied in all patients. Results The clinical recovery times were 48 and 44d,complication rates were 70% and 73%, and fatality rates 10% and 9% respectively in group A and B. There was no statistically significant difference between group A and group B （ P 〉 0.05 ）. Conclusion The curative effect with heparin and 5 - FU on SAP is certain. Small dosage heparin combined with 5 -FU has the same effect as growth inhibitor on SAP.