微量白蛋白尿对冠心病危险的预测价值

Value of Microalbuminuria in Predicting the Risk of Coronary Heart Disease

目的:探讨微量白蛋白尿(MA)对冠心病危险的预测价值。方法:连续入选2004年11月至2005年8月在我院心血管中心住院的320例拟诊冠心病并行冠状动脉造影的患者,对所有患者进行病史采集、常规化验检查,并在入院48小时内测其尿白蛋白滤过率(UAER)。结果:UAER正常低值组、正常高值组、MA组合并三个及以上冠心病危险因素的比例分别是37．6％、51．5％、58％(P<0．05)。MA(UAER≥20μg／min)和UAER≥10μg／min与冠心病发病的OR值分别为 2．12(P<0．01,95％CI:1．19-3．77)和1．69(P<0．05,95％CI:1．01-2．83)。结论:MA是独立于性别、年龄、吸烟、高血压、糖尿病、血脂异常的冠心病的独立危险因素,且在传统定义以下时危险性已增加;UAER越高组合并三个及以上冠心病危险因素的比例越高,检测UAER有助于识别冠心病高危人群。

Objective：To investigate the value of microalbuminuria（MA） in predicting the risk of coronary heart disease（CHD）. Methods： We continuously selected 320 patients who were assumed CHD（2004.11 - 2005.8） . All patients underwent coronary artery angiography, UAER and hemostatie factors evaluation in addition to history collection.Results： The proportion with three or morn risk factors was 37.6%,51.5% ,58%（P 〈0.05） when UAER was at the low-nomad level,high- normal level and MA.The risk ratio of CHD morbidity was 2.12（P 〈 0.01,95%CI： 1.19- 3.77）and 1.69（P 〈 0.05,95% CI： 1.01 - 2.83）when UAER was ≥ 20μg/min and ≥10μg/min.Conclusion： MA was the risk factor of CHD independent of sex, age, smoking, hypertention,diabetes mellitus, dyslipidemia. The risk of CHD had already increased when MA was below the traditional definition. ~ higher UAER, the more risk factors of CHD. UAER was useful in identifying the high risk people of CHD.