Span－1和Ypan－1抗原在胃癌及肠化生组织中的表达

Expression of Span-1 and Ypan-1 Antigens in Gastric Cancer and Intestinal Metaplasia

应用免疫组化方法检测了胰腺癌相关抗原Ｓｐａｎ－１和Ｙｐａｎ－１在１１０例胃癌及３４３例肠上皮化生组织中的表达。结果显示，Ｓｐａｎ－１和Ｙｐａｎ－１在胃癌组织的阳性率分别为７２．７％（８０／１１０）和６５．５％（７２／１１０）；将肠化分为Ⅰ、Ⅱ和Ⅲ型，两种抗原在Ⅲ型肠化阳性率（７９．０％，７５．２％）显著高于Ⅰ型（４２．３％，４５．５％）和Ⅱ型（５１．２％，５０．０％）（Ｐ＜０．０１～０．００１），而Ⅰ型和Ⅱ型间则无显著差别（Ｐ＞０．０５）。以上结果提示，Ⅲ型肠化与胃癌关系密切，应视为胃癌的癌前病变。

Expression of two pancreatic cancer-associated antigens Span-1 and Ypan-1was examined in 110 gastric cancer (GC) and 343 intestinal metaplasia (IM)using immunohistochemical technique. The expression rates of Span-1 and Ypan-1 in GC were 72. 7%(80)110) and 65. 5%(72/110) ,respectively. When IM was classified into type Ⅰ,Ⅱand Ⅲ,the expression rates of both antigens in type Ⅲ (79. 0% , 75. 2%) were significantly higher than those in type Ⅰ (42. 3%, 45. 5%)and type Ⅱ(51. 2%, 50. 0%) (P<0. 01￣0. 001) ,with no difference between type Ⅰ and type Ⅱ (P>0. 05),The results suggest that type Ⅲ IM is closely related to GC and should be considered precancerous.