摘要
The unzipping process of double-stranded DNA is analysed using a discrete model at the base level [Chin. Phys. Lett. 22 （2005）1540]. The numerical results are consistent with the experimental observations on the force-displacement behaviour including the sequence-dependence. We find that the hydrogen bond interaction in a base pair is crucially important to the force-displacement profile.
The unzipping process of double-stranded DNA is analysed using a discrete model at the base level [Chin. Phys. Lett. 22 （2005）1540]. The numerical results are consistent with the experimental observations on the force-displacement behaviour including the sequence-dependence. We find that the hydrogen bond interaction in a base pair is crucially important to the force-displacement profile.
基金
Supported by the National Natural Science Foundation of China under Grant No 10474109, the 100 Persons Project of Chinese Academy of sciences, the Foundation of Ministry of Personnel of China, and Shanghai Supercomputer Center of China.
